Continue to keep this medication in the carton or container it came in, tightly shut, and out of achieve of kids. Keep promethazine tablets and liquid at room temperature and away from surplus warmth and dampness (not in the toilet). Retail store promethazine suppositories within the fridge. Protect the medication from light.

Renal impairment: The kidney is the most important route of elimination, so pharmacokinetics is altered in people with renal impairment. For that reason, clinicians must prescribe codeine at a lessened dose or with lengthier dosing intervals.

Promethazine hydrochloride wasn't mutagenic within the in vitro bacterial reverse mutation assay or clastogenic within the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.

The dose of the drugs might be distinct for various patients. Stick to your medical doctor's orders or maybe the Instructions over the label. The next info incorporates only the normal doses of this medicine. In case your dose differs, never modify it unless your health practitioner lets you know to take action.

This drug might cause you to dizzy or drowsy or blur your vision. Liquor or marijuana (cannabis) may make you extra dizzy or drowsy. Don't travel, use machinery, or do anything that requires alertness or clear eyesight right until you can do it safely and securely.

Make your tax-deductible present and be a Section of the slicing-edge exploration and treatment which is switching medication.

In deciding to use a medicine, the threats of using the drugs have to be weighed towards The nice it is going to do. This is a call you and your medical professional is likely to make. For this medication, the subsequent needs to be considered:

The concomitant usage of Promethazine with Codeine Oral Solution with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may perhaps cause lower codeine ranges, Promethazine codeine syrup greater norcodeine amounts, and fewer metabolism through 2D6 with resultant decreased morphine ranges. This can be linked to a decrease in efficacy, and in certain clients, may well bring about symptoms and signs and symptoms of opioid withdrawal.

Should you be prescribed this medication on a daily routine and pass up a dose, take it as soon as you don't forget. Whether it is close to the time of the subsequent dose, skip the skipped dose. Take your upcoming dose for the regular time. Will not double the dose to capture up.

Promethazine with Codeine Oral Solution contains codeine, a Program V managed material. Being an opioid, Promethazine with Codeine Oral Alternative exposes people for the pitfalls of dependancy, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (nine)], which may result in overdose and death [seeOVERDOSAGE (ten)]. Reserve Promethazine with Codeine Oral Alternative to be used in adult clients for whom the key benefits of cough suppression are anticipated to outweigh the dangers, As well as in whom an sufficient assessment on the etiology in the cough has long been built. Evaluate Every single individual's threat before prescribing Promethazine with Codeine Oral Solution, prescribe Promethazine with Codeine Oral Solution for your shortest duration that's according to person affected person therapy ambitions, keep an eye on all clients regularly for the development of habit or abuse, and refill only following reevaluation of the need for continued remedy.

A most likely lethal symptom intricate in some cases often called Neuroleptic Malignant Syndrome (NMS) has been claimed in Affiliation with promethazine HCl alone or together with antipsychotic medicine.

Doctors prescribe codeine for mild to reasonable acute and Persistent agony, often during most cancers cure or as Component of supportive care for people with significant well being situations.

Proper reports done to this point haven't demonstrated geriatric-certain complications that could limit the usefulness of codeine, phenylephrine, and promethazine combination within the elderly.

Hepatic impairment: Based on maker labeling, no experiments are carried out on sufferers with hepatic impairment. Hence clinicians must prescribe codeine in a lessen dose in these individuals.